New blood test spots tumor-derived DNA for early cancer detection

Updated 2017-08-17 10:31:15 Xinhua

U.S. researchers said Wednesday that they have developed a new test that identified more than half of 138 people with relatively early-stage colorectal, breast, lung and ovarian cancers by detecting tiny amounts of DNA circulating in the blood that originate from tumors.

"This study shows that identifying cancer early using DNA changes in the blood is feasible and that our high accuracy sequencing method is a promising approach to achieve this goal," said Victor Velculescu, professor of oncology at the Johns Hopkins Kimmel Cancer Center, whose study was published in the U.S. journal Science Translational Medicine.

Blood tests for cancer are a growing part of clinical oncology, but they remain in the early stages of development.

To find small bits of cancer-derived DNA in the blood of cancer patients, scientists have frequently relied on DNA alterations found in patients' biopsied tumor samples as guideposts for the genetic mistakes they should be looking for among the masses of DNA circulating in those patients' blood samples.

The challenge is that the test should distinguish between DNA shed from tumors and other altered DNA that can be mistaken for cancer biomarkers.

Most of the time, the blood-derived mutations are not cancer-initiating, and "false positive" results often lead to unnecessary overtesting and overtreatments.

To develop the new test, Velculescu and colleagues obtained blood samples from 200 patients with breast, lung, ovarian and colorectal cancer.

The scientists' blood test screened the patients' blood samples for mutations within 58 genes widely linked to various cancers.

Overall, the scientists were able to detect 86 of 138 stage I and II cancers.

The team also performed independent genomic sequencing on available tumors removed from 100 of the patients and found that 82 had mutations in their tumors that correlated with the genetic alterations found in the blood.

They also tested blood samples of 44 healthy individuals and did not find any cancer-derived mutations.

Despite these initial promising results for early detection, the blood test needs to be validated in studies of much larger numbers of people, said the scientists.

The new blood test is based on deep sequencing, which reads each chemical code in DNA 30,000 times. It's very costly but Velculescu stressed that sequencing technology is becoming cheaper.

He predicted that people that could benefit most from such a DNA-based blood test include those at high risk for cancer including smokers -- for whom standard computed tomography scans for identifying lung cancer often lead to false positives -- and women with hereditary mutations for breast and ovarian cancer within BRCA1 and BRCA2 genes.

Also in the News

Nicole Kidman Recalls Oscar Glory: Loneliest Time
Showbiz2016/06/16 13:58August 16 2018 12:37:13

Nicole Kidman Recalls Oscar Glory: Loneliest Time

Attending Shanghai International Film Festival, Nicole Kidman talks about her role in "Grace of Monaco".

Labor Day Travel Peak Starts
Also in the News2014/05/01 12:16August 16 2018 12:37:13

Labor Day Travel Peak Starts

Johnny Depp Delivers a Speech 'Evolve the Future' in 'Transcendence'
Also in the News2014/04/18 13:18August 16 2018 12:37:13

Johnny Depp Delivers a Speech 'Evolve the Future' in 'Transcendence'

Hollywood star Johnny Depp's speech in the upcoming new film "Transcendence" has been disclosed on Friday, April 11th.

News:
China World Business Sports Showbiz Audio
Video:
C4 My Chinese Life The Sound Stage China Revealed Showbiz Video Travel Video
Photos:
China World Fun Travel Entertainment Sports
Travel:
Beijing Shanghai Guangzhou
Lifestyle:
Live Music Opera & Classical Movies Traditional Shows Exhibitions
Learn Chinese:
Chinese Studio Living Chinese Everyday Chinese Just For Fun Chinese Culture Buzzwords