Scientists close in on origin of SARS

Updated 2017-12-07 10:32:57 China Daily

Researchers believe deadly virus began in bats in Yunnan province

Chinese scientists believe they may have found the origin of the deadly SARS virus in a remote cave in Yunnan province, where they identified a single population of horseshoe bats that harbor virus strains with all the genetic building blocks.

The strain could easily have arisen from such bats, according to research published in PLoS Pathogens on Nov 30. Scientists also warned that the ingredients are in place for a similar disease to emerge again.

Two scientists, Shi Zhengli and Cui Jie from the Wuhan Institute of Virology in Hubei province, led the research team, sampling thousands of wild horseshoe bats from nine provinces. Most caves are located in remote areas, according to Cui.

In one particular cave in Yunnan province, the research team found that the strains of coronavirus looked similar to human versions of SARS. It took five years for researchers to monitor the bats living in the cave.

Severe acute respiratory syndrome, or SARS, is a highly fatal viral disease characterized by fever, headache and respiratory symptoms including cough, difficulties breathing and pneumonia. It emerged in South China in 2002 and rapidly led to a global pandemic, killing almost 800 people worldwide.

The culprit was identified as a strain of coronavirus, and genetically similar viruses were found in masked palm civets that are sold in animal markets in Guangdong province.

Later, a large number of SARS-related coronaviruses were found in horseshoe bats. Scientists believe that the strain probably originated in the bats, and later passed through civets before reaching humans.

The report by the Wuhan team shows multiple incongruent associations between the phylogenies of horseshoe bats and their coronavirus.

"The result showed that host shifts have occurred in the recent evolutionary history of this group. It may be due to either virus biologic traits or host behavioral traits. This finding has implications for the emergence of SARS and for the potential future emergence of SARS-coronavirus or related viruses," the researchers wrote in the report.

Shi told Hubei Daily that wild animals such as bats and rats carry various viruses but spreading across species rarely happens. "There is no need to feel panic about it, but close contact with those wild animals should be prevented," she said.

In a recent interview with Nature Magazine, Tu Changchun, a virologist who directs the OIE Reference Laboratory for Rabies in Changchun, Jilin province, said the results are only 99 percent persuasive.

He said he would like to see scientists demonstrate in the lab that the human SARS strain can jump from bats to another animal, such as a civet. Also, he questioned how a virus from bats in Yunnan could travel to animals and humans about 1,000 kilometers away in Guangdong, without causing any suspected cases in Yunnan.

According to Nature, Cui and Shi also conducted research on other bat populations that could have produced strains capable of infecting humans, and have isolated about 300 bat coronavirus sequences, most not yet published, with which they will continue to monitor the evolution of the virus.

Also in the News

Nicole Kidman Recalls Oscar Glory: Loneliest Time
Showbiz2016/06/16 13:58December 18 2017 05:24:51

Nicole Kidman Recalls Oscar Glory: Loneliest Time

Attending Shanghai International Film Festival, Nicole Kidman talks about her role in "Grace of Monaco".

Labor Day Travel Peak Starts
Also in the News2014/05/01 12:16December 18 2017 05:24:51

Labor Day Travel Peak Starts

Johnny Depp Delivers a Speech 'Evolve the Future' in 'Transcendence'
Also in the News2014/04/18 13:18December 18 2017 05:24:51

Johnny Depp Delivers a Speech 'Evolve the Future' in 'Transcendence'

Hollywood star Johnny Depp's speech in the upcoming new film "Transcendence" has been disclosed on Friday, April 11th.

Most Watched

News:
China World Business Sports Showbiz Audio
Video:
C4 My Chinese Life The Sound Stage China Revealed Showbiz Video Travel Video
Photos:
China World Fun Travel Entertainment Sports
Travel:
Beijing Shanghai Guangzhou
Lifestyle:
Live Music Opera & Classical Movies Traditional Shows Exhibitions
Learn Chinese:
Chinese Studio Living Chinese Everyday Chinese Just For Fun Chinese Culture Buzzwords