U.S. scientists grow hairy skin from mouse cells

Updated 2018-01-03 11:30:19 Xinhua

American scientists have cultured the skin tissue with hairs in a laboratory, using stem cells from mice.

The study, published on Tuesday in Cell Reports, said it lent a clue to the better understanding of hair growth and a new possibility for drug testing.

The study showed that a single skin organoid unit developed in culture can give rise to both the upper and lower layers of skin, and the two layers grew together to allow hair follicles from which the hairs grew to form as they would in a mouse's body.

Karl Koehler, author of the paper and a researcher at the Indiana University School of Medicine, described the tissue like "a little ball of pocket lint that floats around in the culture medium."

"The skin develops as a spherical cyst, and then the hair follicles grow outward in all directions, like dandelion seeds," Koehler said.

Researchers said that the skin grew a variety of hair follicle types similar to those present naturally on the coat of a mouse. It consisted of three or four different types of dermal cells and four types of epidermal cells, making a diverse combination that more closely mimics mouse skin than previously developed skin tissues.

They learnt that the epidermis grew to take the rounded shape of a cyst, then the dermal cells wrapped themselves around these cysts. But when this process was disrupted, hair follicles never appeared.

"It's very important that the cells develop together at an early stage to properly form skin and hair follicles," Koehler said.

None of the previously cultured skin tissues were capable of hair growth.

The rounded shape of the tissue, however, prevented the hairs from shedding and regenerating as the hair follicles grew into the dermal cysts.

Koehler's team believed, once the hair follicles found a way to complete their natural cycle in the culture medium, the organoids were looking to offer more possibilities for medicine and be used as a blueprint to generate human skin organoids.

"It could be potentially a superior model for testing drugs, or looking at things like the development of skin cancers," Koehler said.

Also in the News

Nicole Kidman Recalls Oscar Glory: Loneliest Time
Showbiz2016/06/16 13:58January 23 2019 07:39:47

Nicole Kidman Recalls Oscar Glory: Loneliest Time

Attending Shanghai International Film Festival, Nicole Kidman talks about her role in "Grace of Monaco".

Labor Day Travel Peak Starts
Also in the News2014/05/01 12:16January 23 2019 07:39:47

Labor Day Travel Peak Starts

Johnny Depp Delivers a Speech 'Evolve the Future' in 'Transcendence'
Also in the News2014/04/18 13:18January 23 2019 07:39:47

Johnny Depp Delivers a Speech 'Evolve the Future' in 'Transcendence'

Hollywood star Johnny Depp's speech in the upcoming new film "Transcendence" has been disclosed on Friday, April 11th.

China World Business Sports Showbiz Audio
C4 My Chinese Life The Sound Stage China Revealed Showbiz Video Travel Video
China World Fun Travel Entertainment Sports
Beijing Shanghai Guangzhou
Live Music Opera & Classical Movies Traditional Shows Exhibitions
Learn Chinese:
Chinese Studio Living Chinese Everyday Chinese Just For Fun Chinese Culture Buzzwords